The proteasome cap RPT5/Rpt5p subunit prevents aggregation of unfolded ricin A chain

The plant cytotoxin ricin enters mammalian cells by receptor-mediated endocytosis, undergoing retrograde transport to the ER (endoplasmic reticulum) where its catalytic A chain (RTA) is reductively separated from the holotoxin to enter the cytosol and inactivate ribosomes. The currently accepted mod...

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Detalhes bibliográficos
Main Authors: Pietroni, Paola, Vasisht, Nishi, Cook, Jonathan P., Roberts, David M., Lord, J. Michael, Hartmann-Petersen, Rasmus, Roberts, Lynne M., Spooner, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3778710/
https://ncbi.nlm.nih.gov/pubmed/23617410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20130133
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