Contaminated Heparin Associated with Adverse Clinical Events and Activation of the Contact System

BACKGROUND: There is an urgent need to determine whether oversulfated chondroitin sulfate (OSCS), a compound contaminating heparin supplies worldwide, is the cause of the severe anaphylactoid reactions that have occurred after intravenous heparin administration in the United States and Germany. METH...

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Autores principales: Kishimoto, Takashi Kei, Viswanathan, Karthik, Ganguly, Tanmoy, Elankumaran, Subbiah, Smith, Sean, Pelzer, Kevin, Lansing, Jonathan C., Sriranganathan, Nammalwar, Zhao, Ganlin, Galcheva-Gargova, Zoya, Al-Hakim, Ali, Bailey, Gregory Scott, Fraser, Blair, Roy, Sucharita, Rogers-Cotrone, Thomas, Buhse, Lucinda, Whary, Mark, Fox, James, Nasr, Moheb, Dal Pan, Gerald J., Shriver, Zachary, Langer, Robert S., Venkataraman, Ganesh, Austen, K. Frank, Woodcock, Janet, Sasisekharan, Ram
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3778681/
https://ncbi.nlm.nih.gov/pubmed/18434646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa0803200
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