Ubiquitin-mediated interaction of p210 BCR/ABL with β-catenin supports disease progression in a murine model for chronic myelogenous leukemia

We have identified a ubiquitin-binding domain within the NH(2)-terminal sequences of p210 BCR/ABL and determined that the binding site co-localizes with the binding site for β-catenin. The domain does not support the auto- or trans-kinase activity of p210 BCR/ABL or its ability to interact with GRB2...

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Autors principals: Chen, Ru, Hu, Tinghui, Mahon, Gwendolyn M., Tala, Ilona, Pannucci, Nicole L., Ozer, Harvey L., Whitehead, Ian P.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2013
Matèries:
Myeloid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3778552/
https://ncbi.nlm.nih.gov/pubmed/23950177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-01-481184
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