Formation and repair kinetics of Pt-(GpG) DNA adducts in extracted circulating tumour cells and response to platinum treatment

BACKGROUND: Pt-(GpG) intrastrand crosslinks are the major DNA adducts induced by platinum-based anticancer drugs. In the cell lines and mouse models, the persistence of these lesions correlates significantly with cell damage. Here we studied Pt-(GpG) DNA adducts in circulating tumour cells (CTC) tre...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Nel, I, Gauler, T C, Eberhardt, W E, Nickel, A-C, Schuler, M, Thomale, J, Hoffmann, A-C
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2013
Sujets:
Molecular Diagnostics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3778280/
https://ncbi.nlm.nih.gov/pubmed/23942068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.419
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires