Formation and repair kinetics of Pt-(GpG) DNA adducts in extracted circulating tumour cells and response to platinum treatment

BACKGROUND: Pt-(GpG) intrastrand crosslinks are the major DNA adducts induced by platinum-based anticancer drugs. In the cell lines and mouse models, the persistence of these lesions correlates significantly with cell damage. Here we studied Pt-(GpG) DNA adducts in circulating tumour cells (CTC) tre...

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Detalhes bibliográficos
Main Authors: Nel, I, Gauler, T C, Eberhardt, W E, Nickel, A-C, Schuler, M, Thomale, J, Hoffmann, A-C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3778280/
https://ncbi.nlm.nih.gov/pubmed/23942068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.419
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