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Notch1 promotes the pro-osteogenic response of human aortic valve interstitial cells via modulation of ERK1/2 and NF-κB activation

OBJECTIVE: Calcific aortic valve disease is a leading cardiovascular disease in the elderly, and progressive calcification results in the failure of valvular function. Aortic valve interstitial cells (AVICs) from stenotic valves express higher levels of bone morphogenetic protein-2 (BMP-2) in respon...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zeng, Qingchun, Song, Rui, Ao, Lihua, Weyant, Michael J., Lee, Joon, Xu, Dingli, Fullerton, David A., Meng, Xianzhong
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3778193/
https://ncbi.nlm.nih.gov/pubmed/23640488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.112.300912
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