Loss of calcineurin in the spinal dorsal horn contributes to neuropathic pain and intrathecal administration of the phosphatase provides prolonged analgesia

Calcineurin (protein phosphatase 3) regulates synaptic plasticity in the brain. The development of neuropathic pain appears dependent upon some of the same mechanisms that underlie brain synaptic plasticity. In this study we examined whether calcineurin regulates chronic constriction injury (CCI)-el...

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Bibliographic Details
Main Authors: Miletic, Gordana, Lippitt, Jennifer A., Sullivan, Kristine M., Miletic, Vjekoslav
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3778136/
https://ncbi.nlm.nih.gov/pubmed/23778296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pain.2013.06.019
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