The Endogenous Th17 Response in NO(2)-Promoted Allergic Airway Disease Is Dispensable for Airway Hyperresponsiveness and Distinct from Th17 Adoptive Transfer

Severe, glucocorticoid-resistant asthma comprises 5-7% of patients with asthma. IL-17 is a biomarker of severe asthma, and the adoptive transfer of Th17 cells in mice is sufficient to induce glucocorticoid-resistant allergic airway disease. Nitrogen dioxide (NO(2)) is an environmental toxin that cor...

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Main Authors: Martin, Rebecca A., Ather, Jennifer L., Daggett, Rebecca, Hoyt, Laura, Alcorn, John F., Suratt, Benjamin T., Weiss, Daniel J., Lundblad, Lennart K. A., Poynter, Matthew E.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3778003/
https://ncbi.nlm.nih.gov/pubmed/24069338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0074730
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