Progress of Molecular Targeted Therapies for Advanced Renal Cell Carcinoma

Vascular endothelial growth factor (VEGF) plays a crucial role in tumor angiogenesis. VEGF expression in metastatic renal cell carcinoma (mRCC) is mostly regulated by hypoxia, predominantly via the hypoxia-induced factor (HIF)/Von Hippel-Lindau (VHL) pathway. Advances in our knowledge of VEGF role i...

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Bibliographic Details
Main Authors: Conti, Alessandro, Santoni, Matteo, Amantini, Consuelo, Burattini, Luciano, Berardi, Rossana, Santoni, Giorgio, Cascinu, Stefano, Muzzonigro, Giovanni
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2013
Subjects:
Review Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3777192/
https://ncbi.nlm.nih.gov/pubmed/24093097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/419176
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