Computational analysis of the mutations in BAP1, PBRM1 and SETD2 genes reveals the impaired molecular processes in renal cell carcinoma

Clear cell Renal Cell Carcinoma (ccRCC) is due to loss of von Hippel–Lindau (VHL) gene and at least one out of three chromatin regulating genes BRCA1-associated protein-1 (BAP1), Polybromo-1 (PBRM1) and Set domain-containing 2 (SETD2). More than 350, 700 and 500 mutations are known respectively for...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Piva, Francesco, Giulietti, Matteo, Occhipinti, Giulia, Santoni, Matteo, Massari, Francesco, Sotte, Valeria, Iacovelli, Roberto, Burattini, Luciano, Santini, Daniele, Montironi, Rodolfo, Cascinu, Stefano, Principato, Giovanni
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2015
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741666/
https://ncbi.nlm.nih.gov/pubmed/26452128
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