A Phase II Randomised Controlled Trial Adding Oral Flucytosine to High Dose Fluconazole, with Short-course Amphotericin B, for Cryptococcal Meningitis

BACKGROUND: Cryptococcal meningitis (CM) in Africa is associated with up to 70% mortality at 3 months and 500,000 deaths annually. We examined strategies to improve on fluconazole monotherapy: addition of flucytosine (5-FC); and/or addition of short-course amphotericin B (AmB). METHODS: In step 1, p...

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Detalhes bibliográficos
Main Authors: Jackson, A, Nussbaum, J, Phulusa, J, Namarika, D, Chikasema, M, Kenyemba, C, Jarvis, JN, Jaffar, S, Hosseinipour, MC, van der Horst, C, Harrison, TS
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3776948/
https://ncbi.nlm.nih.gov/pubmed/22526517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0b013e328354b419
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