Combination flucytosine and high dose fluconazole is superior to fluconazole monotherapy for cryptococcal meningitis: a randomized trial in Malawi

BACKGROUND: Cryptococcal meningitis is a major cause of HIV-associated morbidity and mortality in Africa. Improved oral treatment regimens are needed, as amphotericin B is neither available nor feasible in many centers. Fluconazole 1200 mg/d is more fungicidal than 800 mg/d, but mortality remains un...

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Main Authors: Nussbaum, JC, Jackson, A, Namarika, D, Phulusa, J, Kenala, J, Kanyemba, C, Jarvis, JN, Jaffar, S, Hosseinipour, MC, Kamwendo, D, van der Horst, CM, Harrison, TS
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2805957/
https://ncbi.nlm.nih.gov/pubmed/20038244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/649861
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