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Dual p38/JNK Mitogen Activated Protein Kinase Inhibitors Prevent Ozone-Induced Airway Hyperreactivity in Guinea Pigs

Ozone exposure causes airway hyperreactivity and increases hospitalizations resulting from pulmonary complications. Ozone reacts with the epithelial lining fluid and airway epithelium to produce reactive oxygen species and lipid peroxidation products, which then activate cell signaling pathways, inc...

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Detalhes bibliográficos
Main Authors: Verhein, Kirsten C., Salituro, Francesco G., Ledeboer, Mark W., Fryer, Allison D., Jacoby, David B.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3776780/
https://ncbi.nlm.nih.gov/pubmed/24058677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0075351
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