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Macrophage TNF-α mediates parathion-induced airway hyperreactivity in guinea pigs

Organophosphorus pesticides (OPs) are implicated in human asthma. We previously demonstrated that, at concentrations that do not inhibit acetylcholinesterase activity, the OP parathion causes airway hyperreactivity in guinea pigs as a result of functional loss of inhibitory M2 muscarinic receptors o...

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Detalhes bibliográficos
Main Authors: Proskocil, Becky J., Bruun, Donald A., Jacoby, David B., van Rooijen, Nico, Lein, Pamela J., Fryer, Allison D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625991/
https://ncbi.nlm.nih.gov/pubmed/23377347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00381.2012
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