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Mechanistic Insight into the Relationship between N-Terminal Acetylation of α-Synuclein and Fibril Formation Rates by NMR and Fluorescence

Aggregation of α-synuclein (αSyn), the primary protein component in Lewy body inclusions of patients with Parkinson’s disease, arises when the normally soluble intrinsically disordered protein converts to amyloid fibrils. In this work, we provide a mechanistic view of the role of N-terminal acetylat...

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Sonraí Bibleagrafaíochta
Main Authors: Kang, Lijuan, Janowska, Maria K., Moriarty, Gina M., Baum, Jean
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2013
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3776725/
https://ncbi.nlm.nih.gov/pubmed/24058647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0075018
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