Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures

Outside of Fragile X syndrome (FXS), the role of Fragile-X Mental Retardation Protein (FMRP) in mediating neuropsychological abnormalities is not clear. FMRP, p70-S6 kinase (S6K) and protein phosphatase 2A (PP2A) are thought to cooperate as a dynamic signaling complex. In our prior work, adult rats...

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Detalhes bibliográficos
Main Authors: Bernard, Paul B., Castano, Anna M., O’Leary, Heather, Simpson, Kameron, Browning, Michael D., Benke, Tim. A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3775950/
https://ncbi.nlm.nih.gov/pubmed/23831253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2013.06.013
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