Insights into BAY 60-2770 activation and S-nitrosylation-dependent desensitization of soluble guanylyl cyclase via crystal structures of homologous Nostoc H-NOX domain complexes

The soluble guanylyl cyclase (sGC) is an important receptor for nitric oxide (NO). Nitric oxide activates sGC several hundred fold to generate cGMP from GTP. Because of sGC’s salutary roles in cardiovascular physiology, it has received substantial attention as a drug target. The heme domain of sGC i...

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Main Authors: Kumar, Vijay, Martin, Faye, Hahn, Michael G., Schaefer, Martina, Stamler, Jonathan S., Stasch, Johannes-Peter, van den Akker, Focco
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3775905/
https://ncbi.nlm.nih.gov/pubmed/23614626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi301657w
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