Structure of Cinaciguat (BAY 58–2667) Bound to Nostoc H-NOX Domain Reveals Insights into Heme-mimetic Activation of the Soluble Guanylyl Cyclase

Heme is a vital molecule for all life forms with heme being capable of assisting in catalysis, binding ligands, and undergoing redox changes. Heme-related dysfunction can lead to cardiovascular diseases with the oxidation of the heme of soluble guanylyl cyclase (sGC) critically implicated in some of...

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Detalhes bibliográficos
Main Authors: Martin, Faye, Baskaran, Padmamalini, Ma, Xiaolei, Dunten, Pete W., Schaefer, Martina, Stasch, Johannes-Peter, Beuve, Annie, van den Akker, Focco
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903410/
https://ncbi.nlm.nih.gov/pubmed/20463019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.111559
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