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Desensitization of soluble guanylyl cyclase, the NO receptor, by S-nitrosylation
The molecular mechanism of desensitization of soluble guanylyl cyclase (sGC), the NO receptor, has long remained unresolved. Posttranslational modification and redox state have been postulated to affect sGC sensitivity to NO but evidence has been lacking. We now show that sGC can be S-nitrosylated i...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1940331/ https://ncbi.nlm.nih.gov/pubmed/17636120 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0703944104 |
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