BBA, a Synthetic Derivative of 23-hydroxybutulinic Acid, Reverses Multidrug Resistance by Inhibiting the Efflux Activity of MRP7 (ABCC10)

Natural products are frequently used for adjuvant chemotherapy in cancer treatment. 23-O-(1,4'-bipiperidine-1-carbonyl) betulinic acid (BBA) is a synthetic derivative of 23-hydroxybutulinic acid (23-HBA), which is a natural pentacyclic triterpene and the major active constituent of the root of...

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Autori principali: Chen, Jun-Jiang, Patel, Atish, Sodani, Kamlesh, Xiao, Zhi-Jie, Tiwari, Amit K., Zhang, Dong-Mei, Li, Ying-Jie, Yang, Dong-Hua, Ye, Wen-Cai, Chen, Si-Dong, Chen, Zhe-Sheng
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3775757/
https://ncbi.nlm.nih.gov/pubmed/24069321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0074573
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