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Genomic Rearrangements of PTEN in Prostate Cancer
The phosphatase and tensin homolog gene (PTEN) on chromosome 10q23.3 is a negative regulator of the PIK3/Akt survival pathway and is the most frequently deleted tumor suppressor gene in prostate cancer. Monoallelic loss of PTEN is present in up to 60% of localized prostate cancers and complete loss...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3775430/ https://ncbi.nlm.nih.gov/pubmed/24062990 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2013.00240 |
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