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Genomic Rearrangements of PTEN in Prostate Cancer

The phosphatase and tensin homolog gene (PTEN) on chromosome 10q23.3 is a negative regulator of the PIK3/Akt survival pathway and is the most frequently deleted tumor suppressor gene in prostate cancer. Monoallelic loss of PTEN is present in up to 60% of localized prostate cancers and complete loss...

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Detalles Bibliográficos
Main Authors: Phin, Sopheap, Moore, Mathew W., Cotter, Philip D.
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2013
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3775430/
https://ncbi.nlm.nih.gov/pubmed/24062990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2013.00240
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