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CTLA4Ig inhibits effector T cells through regulatory T cells and TGFβ()
The CD28 costimulatory receptor is a critical regulator of T cell function making it an attractive therapeutic target for the treatment of immune mediated diseases. CTLA4Ig, now approved for use in humans, prevents naive T cell activation by binding to B7-proteins and blocking engagement of CD28. Ho...
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| Main Authors: | , , , , , |
|---|---|
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3775269/ https://ncbi.nlm.nih.gov/pubmed/23956428 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1300830 |
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