Combined factor VII/protein C deficiency results in intrauterine coagulopathy in mice

To determine whether an additional loss of the coagulation factor VII (FVII) gene influenced the coagulopathy observed in protein C gene–deficient (PC(–/–)) embryos and neonates, we crossed mice doubly heterozygous for the factor VII (FVII(+/–)) and protein C (PC(+/–)) genes to produce offspring pos...

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Bibliographic Details
Main Authors: Chan, Joyce C.Y., Cornelissen, Ivo, Collen, Desire, Ploplis, Victoria A., Castellino, Francis J.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2000
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC377488/
https://ncbi.nlm.nih.gov/pubmed/10749569
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