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Factor VII deficiency rescues the intrauterine lethality in mice associated with a tissue factor pathway inhibitor deficit

Mice doubly heterozygous for a modified tissue factor pathway inhibitor (TFPI) allele (tfpi(δ)) lacking its Kunitz-type domain-1 (TFPI(+/δ)) and for a deficiency of the factor VII gene (FVII(+/–)) were mated to generate 309 postnatal and 205 embryonic day 17.5 (E17.5) offspring having all the predic...

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Hlavní autoři: Chan, Joyce C.Y., Carmeliet, Peter, Moons, Lieve, Rosen, Elliot D., Huang, Zhong-Fu, Broze, George J., Collen, Désiré, Castellino, Francis J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 1999
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC408108/
https://ncbi.nlm.nih.gov/pubmed/10021455
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