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The Characterization of Mice with a Targeted Combined Deficiency of Protein C and Factor XI

Activated protein C functions directly as an anticoagulant and indirectly as a profibrinolytic enzyme. To determine whether the fibrin deposition previously observed in PC(−/−) murine embryos and neonates was mediated through the FXI pathway, PC(+/−)/FXI(−/−) mice were generated and crossbred to pro...

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Detalhes bibliográficos
Main Authors: Chan, Joyce C. Y., Ganopolsky, Jorge G., Cornelissen, Ivo, Suckow, Mark A., Sandoval-Cooper, Mayra J., Brown, Erica C., Noria, Francisco, Gailani, David, Rosen, Elliot D., Ploplis, Victoria A., Castellino, Francis J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2001
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850297/
https://ncbi.nlm.nih.gov/pubmed/11159184
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