A DOTA-peptide conjugate by copper-free click chemistry

Attachment of DOTA to a novel monofluoro-cyclooctyne facilitates bioconjugation to an azide-modified peptide via Cu-free click chemistry. The resulting conjugate was radiolabeled with (111)In to afford a potential targeted molecular imaging agent with high specific activity and in excellent radioche...

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Bibliografiske detaljer
Main Authors: Martin, Molly E., Parameswarappa, Sharavathi G., O’Dorisio, M. Sue, Pigge, F. Christopher, Schultz, Michael K.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774834/
https://ncbi.nlm.nih.gov/pubmed/20630750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.06.111
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