Prostaglandin G/H synthase-2 is required for maximal formation of osteoclast-like cells in culture

We examined the effect on osteoclast formation of disrupting the prostaglandin G/H synthase genes PGHS-1 and-2. Prostaglandin E(2) (PGE(2)) production was significantly reduced in marrow cultures from mice lacking PGHS-2 (PGHS-2(–/–)) compared with wild-type (PGHS-2(+/+)) cultures. Osteoclast format...

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Autors principals: Okada, Yosuke, Lorenzo, Joseph A., Freeman, Amanda M., Tomita, Masato, Morham, Scott G., Raisz, Lawrence G., Pilbeam, Carol C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2000
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC377461/
https://ncbi.nlm.nih.gov/pubmed/10727451
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