IGF-1 protects retinal ganglion cells from hypoxia-induced apoptosis by activating the Erk-1/2 and Akt pathways

PURPOSE: Hypoxia-induced retinal ganglion cell (RGC) apoptosis has been implicated in many optic neuropathies. Insulin-like growth factor-1 (IGF-1) is important in maintaining neuronal survival, proliferation, and differentiation. The purpose of this study is to explore whether IGF-1 can protect RGC...

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Main Authors: Yang, Xuesen, Wei, Aimin, Liu, Yong, He, Genlin, Zhou, Zhou, Yu, Zhengping
Format: Artigo
Jezik:Inglês
Izdano: Molecular Vision 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774573/
https://ncbi.nlm.nih.gov/pubmed/24049436
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