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Transgenic mice overexpressing insulin-like growth factor-II in β cells develop type 2 diabetes
During embryonic development, insulin-like growth factor-II (IGF-II) participates in the regulation of islet growth and differentiation. We generated transgenic mice (C57BL6/SJL) expressing IGF-II in β cells under control of the rat Insulin I promoter in order to study the role of islet hyperplasia...
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| Publicado no: | J Clin Invest |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC377454/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10727441/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI5656 |
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