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Transgenic mice overexpressing insulin-like growth factor-II in β cells develop type 2 diabetes

During embryonic development, insulin-like growth factor-II (IGF-II) participates in the regulation of islet growth and differentiation. We generated transgenic mice (C57BL6/SJL) expressing IGF-II in β cells under control of the rat Insulin I promoter in order to study the role of islet hyperplasia...

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Sonraí Bibleagrafaíochta
Main Authors: Devedjian, Jean-Christophe, George, Monica, Casellas, Alba, Pujol, Anna, Visa, Joana, Pelegrín, Mireia, Gros, Laurent, Bosch, Fatima
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Clinical Investigation 2000
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC377454/
https://ncbi.nlm.nih.gov/pubmed/10727441
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