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PINK1- Phosphorylated Mitofusin 2 is a Parkin Receptor for Culling Damaged Mitochondria
Senescent and damaged mitochondria undergo selective mitophagic elimination through mechanisms requiring two Parkinson’s disease factors, the mitochondrial kinase PINK1 and the cytosolic ubiquitin ligase Parkin. The nature of the PINK-Parkin interaction and identity of key factors directing Parkin t...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3774525/ https://ncbi.nlm.nih.gov/pubmed/23620051 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1231031 |
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