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Altered de novo lipogenesis contributes to low adipose stores in cystic fibrosis mice

Cystic fibrosis (CF) mouse models exhibit exocrine pancreatic function, yet they do not develop adipose stores to the levels of non-CF mice. CF mice homozygous for the Cftr mutation (F508del) at 3 wk (postweaning) and 6 wk (young adult) of age had markedly less adipose tissue than non-CF mice. Food...

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Autors principals: Bederman, Ilya, Perez, Aura, Henderson, Leigh, Freedman, Joshua A., Poleman, James, Guentert, Dana, Ruhrkraut, Nicholas, Drumm, Mitchell L.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774510/
https://ncbi.nlm.nih.gov/pubmed/22679004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00451.2011
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