A Mixed Mirror-image DNA/RNA Aptamer Inhibits Glucagon and Acutely Improves Glucose Tolerance in Models of Type 1 and Type 2 Diabetes

Excessive secretion of glucagon, a functional insulin antagonist, significantly contributes to hyperglycemia in type 1 and type 2 diabetes. Accordingly, immunoneutralization of glucagon or genetic deletion of the glucagon receptor improved glucose homeostasis in animal models of diabetes. Despite th...

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Dettagli Bibliografici
Autori principali: Vater, Axel, Sell, Simone, Kaczmarek, Przemyslaw, Maasch, Christian, Buchner, Klaus, Pruszynska-Oszmalek, Ewa, Kolodziejski, Pawel, Purschke, Werner G., Nowak, Krzysztof W., Strowski, Mathias Z., Klussmann, Sven
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2013
Soggetti:
Metabolism
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774380/
https://ncbi.nlm.nih.gov/pubmed/23744070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.444414
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