Carbamazepine as a Novel Small Molecule Corrector of Trafficking-impaired ATP-sensitive Potassium Channels Identified in Congenital Hyperinsulinism

ATP-sensitive potassium (K(ATP)) channels consisting of sulfonylurea receptor 1 (SUR1) and the potassium channel Kir6.2 play a key role in insulin secretion by coupling metabolic signals to β-cell membrane potential. Mutations in SUR1 and Kir6.2 that impair channel trafficking to the cell surface le...

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Bibliografiske detaljer
Main Authors: Chen, Pei-Chun, Olson, Erik M., Zhou, Qing, Kryukova, Yelena, Sampson, Heidi M., Thomas, David Y., Shyng, Show-Ling
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2013
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774364/
https://ncbi.nlm.nih.gov/pubmed/23744072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.470948
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