The Amyloid Precursor Protein (APP) Triplicated Gene Impairs Neuronal Precursor Differentiation and Neurite Development through Two Different Domains in the Ts65Dn Mouse Model for Down Syndrome

Intellectual disability in Down syndrome (DS) appears to be related to severe proliferation impairment during brain development. Recent evidence shows that it is not only cellular proliferation that is heavily compromised in DS, but also cell fate specification and dendritic maturation. The amyloid...

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Détails bibliographiques
Auteurs principaux: Trazzi, Stefania, Fuchs, Claudia, Valli, Emanuele, Perini, Giovanni, Bartesaghi, Renata, Ciani, Elisabetta
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2013
Sujets:
Developmental Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774353/
https://ncbi.nlm.nih.gov/pubmed/23740250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.451088
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