Decreased phospho-Akt signaling in a mouse model of total parenteral nutrition: a potential mechanism for the development of intestinal mucosal atrophy

Total parenteral nutrition (TPN) leads to a decline in phosphatidylinositol 3-kinase (PI3K)/phospho-Akt (p-Akt) activity, affecting downstream signaling, reducing epithelial cell (EC) proliferation, and contributing to intestinal mucosal atrophy. We hypothesized that promoting Akt activity would pre...

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Bibliographic Details
Main Authors: Feng, Yongjia, McDunn, Jonathan E., Teitelbaum, Daniel H.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2010
Subjects:
Translational Physiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774331/
https://ncbi.nlm.nih.gov/pubmed/20299605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00030.2010
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