Loss of ADAM17-Mediated Tumor Necrosis Factor Alpha Signaling in Intestinal Cells Attenuates Mucosal Atrophy in a Mouse Model of Parenteral Nutrition

Total parenteral nutrition (TPN) is commonly used clinically to sustain patients; however, TPN is associated with profound mucosal atrophy, which may adversely affect clinical outcomes. Using a mouse TPN model, removing enteral nutrition leads to decreased crypt proliferation, increased intestinal e...

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Vydáno v:Mol Cell Biol
Hlavní autoři: Feng, Yongjia, Tsai, Yu-Hwai, Xiao, Weidong, Ralls, Matthew W., Stoeck, Alex, Wilson, Carole L., Raines, Elaine W., Teitelbaum, Daniel H., Dempsey, Peter J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4589604/
https://ncbi.nlm.nih.gov/pubmed/26283731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00143-15
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