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Inflammation-mediated Notch signaling skews Fanconi Anemia hematopoietic stem cell differentiation

Hematopoietic stem cells (HSCs) can either self-renew or differentiate into various types of cells of the blood lineage. Signaling pathways that regulate this choice of self-renewal versus differentiation are currently under extensive investigation. Here we report that deregulation of Notch signalin...

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Detalhes bibliográficos
Main Authors: Du, Wei, Amarachintha, Surya, Sipple, Jared, Schick, Jonathan, Steinbrecher, Kris, Pang, Qishen
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3773980/
https://ncbi.nlm.nih.gov/pubmed/23926327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1203474
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