The transcription factor Interferon Regulatory Factor 4 is required for the generation of protective effector CD8(+) T cells

Robust cytotoxic CD8(+) T-cell response is important for immunity to intracellular pathogens. Here, we show that the transcription factor IFN Regulatory Factor 4 (IRF4) is crucial for the protective CD8(+) T-cell response to the intracellular bacterium Listeria monocytogenes. IRF4-deficient (Irf4(−/...

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Autori principali: Raczkowski, Friederike, Ritter, Josephine, Heesch, Kira, Schumacher, Valéa, Guralnik, Anna, Höcker, Lena, Raifer, Hartmann, Klein, Matthias, Bopp, Tobias, Harb, Hani, Kesper, Dörthe A., Pfefferle, Petra I., Grusdat, Melanie, Lang, Philipp A., Mittrücker, Hans-Willi, Huber, Magdalena
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2013
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3773801/
https://ncbi.nlm.nih.gov/pubmed/23980171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1309378110
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