Ether lipid generating enzyme AGPS alters the balance of structural and signaling lipids to fuel cancer pathogenicity

Aberrant lipid metabolism is an established hallmark of cancer cells. In particular, ether lipid levels have been shown to be elevated in tumors, but their specific function in cancer remains elusive. We show here that the metabolic enzyme alkylglyceronephosphate synthase (AGPS), a critical step in...

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Bibliografiske detaljer
Main Authors: Benjamin, Daniel I., Cozzo, Alyssa, Ji, Xiaodan, Roberts, Lindsay S., Louie, Sharon M., Mulvihill, Melinda M., Luo, Kunxin, Nomura, Daniel K.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3773741/
https://ncbi.nlm.nih.gov/pubmed/23980144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1310894110
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