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Discovery of Inhibitors for the Ether Lipid-Generating Enzyme AGPS as Anti-Cancer Agents

Dysregulated ether lipid metabolism is an important hallmark of cancer cells. Previous studies have reported that lowering ether lipid levels by genetic ablation of the ether lipid-generating enzyme alkyl-glycerone phosphate synthase (AGPS) lowers key structural and oncogenic ether lipid levels and...

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Vydáno v:ACS Chem Biol
Hlavní autoři: Piano, Valentina, Benjamin, Daniel I, Valente, Sergio, Nenci, Simone, Mai, Antonello, Aliverti, Alessandro, Nomura, Daniel K, Mattevi, Andrea
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703096/
https://ncbi.nlm.nih.gov/pubmed/26322624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00466
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