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Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons
Presenilin (PS) plays a central role in the pathogenesis of Alzheimer’s disease, and loss of PS causes progressive memory impairment and age-related neurodegeneration in the mouse cerebral cortex. In hippocampal neurons, PS is essential for neurotransmitter release, NMDA receptor-mediated responses,...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3773738/ https://ncbi.nlm.nih.gov/pubmed/23918386 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1304171110 |
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