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Pre-treatment with a PKC or PKA inhibitor prevents the development of morphine tolerance but not physical dependence in mice

We previously demonstrated that intracerebroventricular (i.c.v.) administration of protein kinase C (PKC) or protein kinase A (PKA) inhibitors reversed morphine antinociceptive tolerance in 3-day morphine-pelleted mice. The present study aimed at evaluating whether pre-treating mice with a PKC or PK...

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Detalhes bibliográficos
Main Authors: Gabra, Bichoy H., Bailey, Chris P., Kelly, Eamonn, Smith, Forrest L., Henderson, Graeme, Dewey, William L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3773693/
https://ncbi.nlm.nih.gov/pubmed/18501877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2008.04.036
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