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Pre-treatment with a PKC or PKA inhibitor prevents the development of morphine tolerance but not physical dependence in mice
We previously demonstrated that intracerebroventricular (i.c.v.) administration of protein kinase C (PKC) or protein kinase A (PKA) inhibitors reversed morphine antinociceptive tolerance in 3-day morphine-pelleted mice. The present study aimed at evaluating whether pre-treating mice with a PKC or PK...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2008
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3773693/ https://ncbi.nlm.nih.gov/pubmed/18501877 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2008.04.036 |
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