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Evidence for an important role of protein phosphatases in the mechanism of morphine tolerance
Acute morphine antinociception has been shown to be blocked by very low picogram doses of okadaic acid indicating that inhibition of protein phosphatase PP2A allows for increases in phosphorylation to inhibit antinociception. Comparative studies in morphine tolerant animals have not been reported. I...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3736353/ https://ncbi.nlm.nih.gov/pubmed/17582387 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2007.05.017 |
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