P-glycoprotein Inhibition Increases the Brain Distribution and Antidepressant-Like Activity of Escitalopram in Rodents

Despite the clinical prevalence of the antidepressant escitalopram, over 30% of escitalopram-treated patients fail to respond to treatment. Recent gene association studies have highlighted a potential link between the drug efflux transporter P-glycoprotein (P-gp) and response to escitalopram. The pr...

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Detalhes bibliográficos
Main Authors: O'Brien, Fionn E, O'Connor, Richard M, Clarke, Gerard, Dinan, Timothy G, Griffin, Brendan T, Cryan, John F
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3773671/
https://ncbi.nlm.nih.gov/pubmed/23670590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2013.120
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