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Chronic P‐glycoprotein inhibition increases the brain concentration of escitalopram: potential implications for treating depression
Recent preclinical studies have revealed a functionally important role for the drug efflux pump P‐glycoprotein (P‐gp) at the blood–brain barrier in limiting brain levels and thus antidepressant‐like activity of certain antidepressant drugs. Specifically, acute administration of P‐gp inhibitors, such...
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| Publicado no: | Pharmacol Res Perspect |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4777256/ https://ncbi.nlm.nih.gov/pubmed/27022464 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.190 |
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