miR-221 silencing blocks hepatocellular carcinoma and promotes survival

Patients with advanced hepatocellular carcinoma (HCC) face a dismal prognosis due to a lack of any effective therapies. To address this situation, we conducted a preclinical investigation of the therapeutic efficacy of oligonucleotides directed against the oncogenic microRNA miR-221 which has been i...

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Bibliografiske detaljer
Main Authors: Park, Jong-Kook, Kogure, Takayuki, Nuovo, Gerard J., Jiang, Jinmai, He, Lei, Kim, Ji Hye, Phelps, Mitch A., Papenfuss, Tracey L., Croce, Carlo M., Patel, Tushar, Schmittgen, Thomas D.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3773601/
https://ncbi.nlm.nih.gov/pubmed/22009537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-1144
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