Methylation Mediated Silencing of MicroRNA-1 Gene and Its Role in Hepatocellular Carcinogenesis

MicroRNAs (miRs) are a class of small (~21 nucleotide) noncoding RNAs that, in general, negatively regulate gene expression. Some miRs harboring CpG islands (CGIs) undergo methylation-mediated silencing, a characteristic of many tumor suppressor genes. To identify such miRs in liver cancer the micro...

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Detalhes bibliográficos
Main Authors: Datta, Jharna, Kutay, Huban, Nasser, Mohd W., Nuovo, Gerard J., Wang, Bo, Majumder, Sarmila, Liu, Chang-Gong, Volinia, Stefano, Croce, Carlo M., Schmittgen, Thomas D., Ghoshal, Kalpana, Jacob, Samson T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2562630/
https://ncbi.nlm.nih.gov/pubmed/18593903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-6655
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