Changes in serum-free light chain rather than intact monoclonal immunoglobulin levels predicts outcome following therapy in primary amyloidosis

Current response criteria for light-chain amyloidosis (AL) relegate FLC response to a subsidiary status relative to serum M-protein response. Given that light chains form the substrate for amyloid fibril formation, we hypothesized that changes in FLC might better predict outcome compared to changes...

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Main Authors: Kumar, Shaji K., Dispenzieri, Angela, Lacy, Martha Q., Hayman, Suzanne R., Buadi, Francis K., Zeldenrust, Steven R., Tan, Tow, Sinha, Shirshendu, Leung, Nelson, Kyle, Robert A., Rajkumar, S. Vincent, Gertz, Morie A.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3773466/
https://ncbi.nlm.nih.gov/pubmed/21328431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajh.21948
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